Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide

Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide

Human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII were investigated for their inhibitory activity with a series of new Schiff’s bases based on quinazoline scaffold <b>4</b>–<b>27</b>. The hCA I isoform was efficiently inhibited by Schiff’s bases <...

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Bibliographic Details
Main Authors: Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hazem A. Ghabbour, Silvia Bua, Alessio Nocentini, Hamad M. Alkahtani, Nawaf A. Alsaif, Mohamed H. M. Al-Agamy, Claudiu T. Supuran
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
quinazolinones
sulfonamide
schiff’s bases
selectivity CA inhibitors
Online Access:https://www.mdpi.com/1420-3049/27/22/7703

Internet

https://www.mdpi.com/1420-3049/27/22/7703

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