Sarco/Endoplasmic Reticulum Ca<sup>2+</sup> ATPase 2 Activator Ameliorates Endothelial Dysfunction; Insulin Resistance in Diabetic Mice

Sarco/Endoplasmic Reticulum Ca<sup>2+</sup> ATPase 2 Activator Ameliorates Endothelial Dysfunction; Insulin Resistance in Diabetic Mice

<b>Background:</b> Sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase2 (SERCA2) is impaired in various organs in animal models of diabetes. The purpose of this study was to test the effects of an allosteric SERCA2 activator (CDN1163) on glucose intolerance, hepatosteatosis, s...

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Bibliographic Details
Main Authors: Toyokazu Kimura, Kazuki Kagami, Atsushi Sato, Ayumu Osaki, Kei Ito, Shunpei Horii, Takumi Toya, Nobuyuki Masaki, Risako Yasuda, Yuji Nagatomo, Takeshi Adachi
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
type 2 diabetes mellitus
sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase2
endothelial function
skeletal muscle function
endoplasmic reticulum stress
Online Access:https://www.mdpi.com/2073-4409/11/9/1488

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https://www.mdpi.com/2073-4409/11/9/1488

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