Type I Interferon, Induced by Adenovirus or Adenoviral Vector Infection, Regulates the Cytokine Response to Lipopolysaccharide in a Macrophage Type-Specific Manner

Type I Interferon, Induced by Adenovirus or Adenoviral Vector Infection, Regulates the Cytokine Response to Lipopolysaccharide in a Macrophage Type-Specific Manner

Introduction: While TLR ligands derived from microbial flora and pathogens are important activators of the innate immune system, a variety of factors such as intracellular bacteria, viruses, and parasites can induce a state of hyperreactivity, causing a dysregulated and potentially life-threatening...

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Main Authors: Mareike D. Maler, Sophie Zwick, Carsten Kallfass, Peggy Engelhard, Hexin Shi, Laura Hellig, Pang Zhengyang, Annika Hardt, Gernot Zissel, Zsolt Ruzsics, Willi Jahnen-Dechent, Stefan F. Martin, Peter Jess Nielsen, Daiana Stolz, Justyna Lopatecka, Sarah Bastyans, Bruce Beutler, Wolfgang W. Schamel, György Fejer, Marina Alexandra Freudenberg
Format: Article
Language:English
Published: Karger Publishers 2024-03-01
Series:Journal of Innate Immunity
Subjects:
lipopolysaccharide
adenoviral vector
macrophages
ifn-αβ
cytokines
Online Access:https://beta.karger.com/Article/FullText/538282

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https://beta.karger.com/Article/FullText/538282

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