Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy

Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy

Androgen receptor (AR) signaling remains the major oncogenic pathway in prostate cancer (PCa). Androgen-deprivation therapy (ADT) is the principle treatment for locally advanced and metastatic disease. However, a significant number of patients acquire treatment resistance leading to castration resis...

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Bibliographic Details
Main Authors: Vito Cucchiara, Joy C. Yang, Vincenzo Mirone, Allen C. Gao, Michael G. Rosenfeld, Christopher P. Evans
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Cancers
Subjects:
epigenetics
prostate cancer
androgen receptor
methylation
acetylation
non-coding RNA
biomarkers
novel treatments
Online Access:http://www.mdpi.com/2072-6694/9/1/9

Internet

http://www.mdpi.com/2072-6694/9/1/9

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