Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis

Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis

Abnormal proliferation of aggressive fibroblast-like synoviocytes (FLS) and perpetuate synovial inflammation can inevitably accelerate the progression of rheumatoid arthritis (RA). Herein, a strategy of simultaneously promoting FLS apoptosis and inhibiting inflammation as mediated by macrophages is...

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Bibliographic Details
Main Authors: Peng Hua, Ruifeng Liang, Suleixin Yang, Yanbei Tu, Meiwan Chen
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-06-01
Series:Bioactive Materials
Subjects:
Rheumatoid arthritis
PUMA
Celastrol
Anti-inflammation
Fibroblast-like synoviocyte apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24000756

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http://www.sciencedirect.com/science/article/pii/S2452199X24000756

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