Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment

Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment

Nup358, a protein of the nuclear pore complex, facilitates a nuclear positioning pathway that is essential for many biological processes, including neuromuscular and brain development. Nup358 interacts with the dynein adaptor Bicaudal D2 (BicD2), which in turn recruits the dynein machinery to positi...

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Bibliographic Details
Main Authors: James M Gibson, Heying Cui, M Yusuf Ali, Xiaoxin Zhao, Erik W Debler, Jing Zhao, Kathleen M Trybus, Sozanne R Solmaz, Chunyu Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
bidirectional transport
dynein
nuclear positioning
NMR
TIRF
BicD2
Online Access:https://elifesciences.org/articles/74714

Internet

https://elifesciences.org/articles/74714

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