Human Endonuclease ANKLE1 Localizes at the Midbody and Processes Chromatin Bridges to Prevent DNA Damage and cGAS‐STING Activation

Human Endonuclease ANKLE1 Localizes at the Midbody and Processes Chromatin Bridges to Prevent DNA Damage and cGAS‐STING Activation

Abstract Chromatin bridges connecting the two segregating daughter nuclei arise from chromosome fusion or unresolved interchromosomal linkage. Persistent chromatin bridges are trapped in the cleavage plane, triggering cytokinesis delay. The trapped bridges occasionally break during cytokinesis, indu...

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Bibliographic Details
Main Authors: Huadong Jiang, Nannan Kong, Zeyuan Liu, Stephen C. West, Ying Wai Chan
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Advanced Science
Subjects:
ANKLE1
cGAS‐STING
chromatin bridge
micronucleus
midbody
Online Access:https://doi.org/10.1002/advs.202204388

Internet

https://doi.org/10.1002/advs.202204388

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