Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance

Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance

Chimeric antigen receptor (CAR)-T cells already showed impressive clinical regressions in leukemia and lymphoma. However, the development of CAR-T cells against solid tumors lags behind. Here we present the clinical-scale production of CAR-T cells for the treatment of melanoma under full GMP complia...

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Bibliographic Details
Main Authors: Manuel Wiesinger, Johannes März, Mirko Kummer, Gerold Schuler, Jan Dörrie, Beatrice Schuler-Thurner, Niels Schaft
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
CAR-T cell
melanoma
CSPG4
clinical scale production
full GMP compliance
clinical study
consistency runs
Online Access:https://www.mdpi.com/2072-6694/11/8/1198

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https://www.mdpi.com/2072-6694/11/8/1198

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