Transcription and chromatin determinants of de novo DNA methylation timing in oocytes

Transcription and chromatin determinants of de novo DNA methylation timing in oocytes

Abstract Background Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as a consequence of transcription events. Molecular and functional...

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Bibliographic Details
Main Authors: Lenka Gahurova, Shin-ichi Tomizawa, Sébastien A. Smallwood, Kathleen R. Stewart-Morgan, Heba Saadeh, Jeesun Kim, Simon R. Andrews, Taiping Chen, Gavin Kelsey
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Epigenetics & Chromatin
Subjects:
Oocytes
DNA methylation
Histone modifications
Transcription
Imprinting
Online Access:http://link.springer.com/article/10.1186/s13072-017-0133-5

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http://link.springer.com/article/10.1186/s13072-017-0133-5

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