Role of a Novel Heparanase Inhibitor on the Balance between Apoptosis and Autophagy in U87 Human Glioblastoma Cells

Role of a Novel Heparanase Inhibitor on the Balance between Apoptosis and Autophagy in U87 Human Glioblastoma Cells

Background: Heparanase (HPSE) is an endo-β-glucuronidase that cleaves heparan sulfate side chains, leading to the disassembly of the extracellular matrix, facilitating cell invasion and metastasis dissemination. In this research, we investigated the role of a new HPSE inhibitor, RDS 3337, in the reg...

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Bibliographic Details
Main Authors: Valeria Manganelli, Roberta Misasi, Gloria Riitano, Antonella Capozzi, Vincenzo Mattei, Tuba Rana Caglar, Davide Ialongo, Valentina Noemi Madia, Antonella Messore, Roberta Costi, Roberto Di Santo, Maurizio Sorice, Tina Garofalo
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
heparanase inhibitor
apoptosis
autophagy
U87 human glioblastoma cells
Online Access:https://www.mdpi.com/2073-4409/12/14/1891

Internet

https://www.mdpi.com/2073-4409/12/14/1891

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