The role of interleukin-18 and interleukin-18 binding protein in K/BxN serum transfer-induced arthritis

BackgroundInterleukin-18 is a proinflammatory cytokine, the activity of which is regulated by its natural inhibitor, IL-18 binding protein (IL-18BP). Elevated circulating levels of IL-18 have been observed in patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease...

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Bibliographic Details
Main Authors: Sebastien Fauteux-Daniel, Laura M. Merlo Pich, Charlotte Girard-Guyonvarc’h, Assunta Caruso, Emiliana Rodriguez, Cem Gabay
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1215364/full