CLICK-chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells

CLICK-chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells

Pregnenolone (P5) is synthesized as the first bioactive steroid in the mitochondria from cholesterol. Clusters of differentiation 4 (CD4+) and Clusters of differentiation 8 (CD8+) immune cells synthesize P5 de novo; P5, in turn, play important role in immune homeostasis and regulation. However, P5’s...

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Bibliographic Details
Main Authors: Sougata Roy, Sudeep Roy, Bidesh Mahata, Jhuma Pramanik, Marco L. Hennrich, Anne-Claude Gavin, Sarah A. Teichmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
pregnenolone
lymphosteroid
chemoproteomics
TH2
click chemistry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1229703/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1229703/full

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