APOEε4 and risk of Alzheimer’s disease – time to move forward

The inheritance of Apolipoprotein E4 (APOEε4) brings the highest genetic risk of Alzheimer’s disease (AD), arguably the highest genetic risk in human pathology. Since the discovery of the association, APOE protein isoforms have been at the center of tens of thousands of studies and reports. While, w...

Full description

Bibliographic Details
Main Authors: Iliya Lefterov, Nicholas F. Fitz, Yi Lu, Radosveta Koldamova
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1195724/full