MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage

MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage

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Abstract Background The functional neurological outcome of patients with intracerebral hemorrhage (ICH) strongly relates to the degree of secondary brain injury (ICH-SBI) evolving within days after the initial bleeding. Different mechanisms including the incitement of inflammatory pathways, dysfunct...

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Bibliographic Details
Main Authors: Kevin Akeret, Raphael M. Buzzi, Bart R. Thomson, Nina Schwendinger, Jan Klohs, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Luca Regli, Florence Vallelian, Michael Hugelshofer, Dominik J. Schaer
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Secondary brain injury
Glymphatics
Spatial RNA sequencing
Quantitative histology
Online Access:https://doi.org/10.1186/s12974-022-02641-5

Internet

https://doi.org/10.1186/s12974-022-02641-5

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