Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization

Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization

Abstract Background Spinal cord ischemia-reperfusion injury (SCIRI) often leads to neurological damage and mortality. In this regard, understanding the pathology of SCIRI and preventing its development are of great clinic value. Methods Herein, we analyzed the role of bone marrow mesenchymal stem ce...

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Bibliographic Details
Main Authors: Ran Li, Kunchi Zhao, Qing Ruan, Chunyang Meng, Fei Yin
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Arthritis Research & Therapy
Subjects:
Spinal cord ischemia-reperfusion injury
Exosome
MicroRNA-124-3p
Ern1
Macrophage M2
Online Access:http://link.springer.com/article/10.1186/s13075-020-2146-x

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http://link.springer.com/article/10.1186/s13075-020-2146-x

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