Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target

Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target

Approximately 50% of prostate cancers harbor the TMPRSS2:ERG fusion, resulting in elevated expression of the ERG transcription factor. Despite the identification of this subclass of prostate cancers, no personalized therapeutic strategies have achieved clinical implementation. Kinases are attractive...

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Bibliographic Details
Main Authors: Rachel S Lee, Luxi Zhang, Adeline Berger, Mitchell G Lawrence, Jiangning Song, Birunthi Niranjan, Rebecca G Davies, Natalie L Lister, Shahneen K Sandhu, Mark A Rubin, Gail P Risbridger, Renea A Taylor, David S Rickman, Lisa G Horvath, Roger J Daly
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558618305001

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http://www.sciencedirect.com/science/article/pii/S1476558618305001

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