Synthesis and Cytotoxicity Studies of Novel NHC*-Gold(I) Complexes Derived from Lepidiline A

Synthesis and Cytotoxicity Studies of Novel NHC*-Gold(I) Complexes Derived from Lepidiline A

Ten novel N-heterocyclic carbene gold(I) complexes derived from lepidiline A (1,3-dibenzyl-4,5-dimethylimidazolium chloride) are reported here with full characterisation and biological testing. (1,3-Dibenzyl-4,5-diphenylimidazol-2-ylidene)gold(I) chloride (NHC*-AuCl) (1) was modified by substituting...

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Bibliographic Details
Main Authors: Danielle Curran, Oyinlola Dada, Helge Müller-Bunz, Matthias Rothemund, Goar Sánchez-Sanz, Rainer Schobert, Xiangming Zhu, Matthias Tacke
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
lepidiline A
N-heterocyclic carbene
gold anticancer drug
TrxR inhibition
MTT cytotoxicity assay
DFT calculations
Online Access:http://www.mdpi.com/1420-3049/23/8/2031

Internet

http://www.mdpi.com/1420-3049/23/8/2031

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