A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome

A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome

Summary: Patients with mtDNA depletion syndrome 3 (MTDPS3) often die as children from liver failure caused by severe reduction in mtDNA content. The identification of treatments has been impeded by an inability to culture and manipulate MTDPS3 primary hepatocytes. Here we generated DGUOK-deficient h...

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Bibliographic Details
Main Authors: Ran Jing, James L. Corbett, Jun Cai, Gyda C. Beeson, Craig C. Beeson, Sherine S. Chan, David P. Dimmock, Lynn Lazcares, Aron M. Geurts, John J. Lemasters, Stephen A. Duncan
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316127

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http://www.sciencedirect.com/science/article/pii/S2211124718316127

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