A semi-automated pipeline for quantifying drusen-like deposits in human induced pluripotent stem cell-derived retinal pigment epithelium cells

A semi-automated pipeline for quantifying drusen-like deposits in human induced pluripotent stem cell-derived retinal pigment epithelium cells

Age-Related Macular Degeneration (AMD) is a highly prevalent form of retinal disease amongst Western communities over 50 years of age. A hallmark of AMD pathogenesis is the accumulation of drusen underneath the retinal pigment epithelium (RPE), a biological process also observable in vitro. The accu...

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Bibliographic Details
Main Authors: Jenna Hall, Maciej Daniszewski, Shane Cheung, Kalyan Shobhana, Himeesh Kumar, Helena H Liang, Henry Beetham, Ellie Cho, Carla Abbott, Alex W Hewitt, Kaylene J Simpson, Robyn H Guymer, Daniel Paull, Alice Pébay, Grace E. Lidgerwood
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:SLAS Technology
Subjects:
Retinal pigment epithelium
Confocal microscopy
Drusen
Age-related macular degeneration
Quantification
Reticular pseudodrusen
Online Access:http://www.sciencedirect.com/science/article/pii/S2472630323000559

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http://www.sciencedirect.com/science/article/pii/S2472630323000559

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