Tryptase activates enteric glial cells followed by affecting neuronal properties possibly via the stimuli-associated mediators

Objectives: Mast cell-derived tryptase causes neuronal elongation/sensitization leading to visceral hypersensitivity. However, effects of tryptase on enteric glial cells (EGCs) and subsequent interaction between EGCs and neurons remain unknown. Methods: We evaluated proteins and mRNA expressions in...

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Bibliographic Details
Main Authors: Kazunari Tominaga, Yoshiko Fujikawa
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Journal of Pharmacological Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861323000063