Progress towards a glycoconjugate vaccine against Group A Streptococcus

Abstract The Group A Carbohydrate (GAC) is a defining feature of Group A Streptococcus (Strep A) or Streptococcus pyogenes. It is a conserved and simple polysaccharide, comprising a rhamnose backbone and GlcNAc side chains, further decorated with glycerol phosphate on approximately 40% GlcNAc residu...

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Bibliographic Details
Main Authors: Keira Burns, Helge C. Dorfmueller, Brendan W. Wren, Fatme Mawas, Helen A. Shaw
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00639-5