Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA.

Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA.

Previous work has demonstrated the presence of ribonucleotides in human mitochondrial DNA (mtDNA) and in the present study we use a genome-wide approach to precisely map the location of these. We find that ribonucleotides are distributed evenly between the heavy- and light-strand of mtDNA. The relat...

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Bibliographic Details
Main Authors: Anna-Karin Berglund, Clara Navarrete, Martin K M Engqvist, Emily Hoberg, Zsolt Szilagyi, Robert W Taylor, Claes M Gustafsson, Maria Falkenberg, Anders R Clausen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5336301?pdf=render

Internet

http://europepmc.org/articles/PMC5336301?pdf=render

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