Testing Proximity of Genomic Regions to Transcription Start Sites and Enhancers Complements Gene Set Enrichment Testing

Testing Proximity of Genomic Regions to Transcription Start Sites and Enhancers Complements Gene Set Enrichment Testing

Large sets of genomic regions are generated by the initial analysis of various genome-wide sequencing data, such as ChIP-seq and ATAC-seq experiments. Gene set enrichment (GSE) methods are commonly employed to determine the pathways associated with them. Given the pathways and other gene sets (e.g.,...

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Bibliographic Details
Main Authors: Christopher Lee, Kai Wang, Tingting Qin, Maureen A. Sartor
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Genetics
Subjects:
gene set enrichment test
ChIP-seq data analysis
non-parametric test
pathway analysis
genomic regions
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00199/full

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https://www.frontiersin.org/article/10.3389/fgene.2020.00199/full

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