Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

Summary: Reliable, easy-to-handle phenotypic screening platforms are needed for the identification of anti-SARS-CoV-2 compounds. Here, we present caspase 3/7 activity as a readout for monitoring the replication of SARS-CoV-2 isolates from different variants, including a remdesivir-resistant strain,...

Full description

Bibliographic Details
Main Authors: Denisa Bojkova, Philipp Reus, Leona Panosch, Marco Bechtel, Tamara Rothenburger, Joshua D. Kandler, Annika Pfeiffer, Julian U.G. Wagner, Mariana Shumliakivska, Stefanie Dimmeler, Ruth Olmer, Ulrich Martin, Florian W.R. Vondran, Tuna Toptan, Florian Rothweiler, Richard Zehner, Holger F. Rabenau, Karen L. Osman, Steven T. Pullan, Miles W. Carroll, Richard Stack, Sandra Ciesek, Mark N. Wass, Martin Michaelis, Jindrich Cinatl, Jr.
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Virology
Drugs
Screening in health technology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223000214

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223000214

Similar Items