RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing

RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing

Abstract The conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the RNA sequence(s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 during the splicing reaction remain elusive. Here, we developed a split-iCRAC approach in yeast to uncover the consensus...

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Bibliographic Details
Main Authors: Ahmed Moursy, Antoine Cléry, Stefan Gerhardy, Katharina M. Betz, Sanjana Rao, Jarosław Mazur, Sébastien Campagne, Irene Beusch, Malgorzata M. Duszczyk, Mark D. Robinson, Vikram Govind Panse, Frédéric H.-T. Allain
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42962-4

Internet

https://doi.org/10.1038/s41467-023-42962-4

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