The Intersection of Purine and Mitochondrial Metabolism in Cancer
Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/10/2603 |
| _version_ | 1797514993561763840 |
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| author | Humberto De Vitto Danushka B. Arachchige Brian C. Richardson Jarrod B. French |
| author_facet | Humberto De Vitto Danushka B. Arachchige Brian C. Richardson Jarrod B. French |
| author_sort | Humberto De Vitto |
| collection | DOAJ |
| description | Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment. |
| first_indexed | 2024-03-10T06:39:23Z |
| format | Article |
| id | doaj.art-4a892da73f544fd7a79a5f8c605cd9e9 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:39:23Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4a892da73f544fd7a79a5f8c605cd9e92023-11-22T17:46:15ZengMDPI AGCells2073-44092021-09-011010260310.3390/cells10102603The Intersection of Purine and Mitochondrial Metabolism in CancerHumberto De Vitto0Danushka B. Arachchige1Brian C. Richardson2Jarrod B. French3Division of Nucleotide Metabolism & Drug Discovery, The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USADivision of Nucleotide Metabolism & Drug Discovery, The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USADivision of Nucleotide Metabolism & Drug Discovery, The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USADivision of Nucleotide Metabolism & Drug Discovery, The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USANucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment.https://www.mdpi.com/2073-4409/10/10/2603purinesmitochondrial metabolismamino acidsmetabolic reprogrammingcancers |
| spellingShingle | Humberto De Vitto Danushka B. Arachchige Brian C. Richardson Jarrod B. French The Intersection of Purine and Mitochondrial Metabolism in Cancer Cells purines mitochondrial metabolism amino acids metabolic reprogramming cancers |
| title | The Intersection of Purine and Mitochondrial Metabolism in Cancer |
| title_full | The Intersection of Purine and Mitochondrial Metabolism in Cancer |
| title_fullStr | The Intersection of Purine and Mitochondrial Metabolism in Cancer |
| title_full_unstemmed | The Intersection of Purine and Mitochondrial Metabolism in Cancer |
| title_short | The Intersection of Purine and Mitochondrial Metabolism in Cancer |
| title_sort | intersection of purine and mitochondrial metabolism in cancer |
| topic | purines mitochondrial metabolism amino acids metabolic reprogramming cancers |
| url | https://www.mdpi.com/2073-4409/10/10/2603 |
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