Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques

Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques

Abstract Introduction Current approaches for treating sporadic Alzheimer's disease (sAD) focus on removal of amyloid beta 1‐42 (Aβ1‐42) or phosphorylated tau, but additional strategies are needed to reduce neuropathology at earlier stages prior to neuronal damage. Longstanding data show that ca...

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Bibliographic Details
Main Authors: Shveta Bathla, Dibyadeep Datta, Feng Liang, Nicolas Barthelemy, Robyn Wiseman, Barbara S Slusher, Jennifer Asher, Caroline Zeiss, Dil Ekanayake‐Alper, Daniel Holden, Gordon Terwilliger, Alvaro Duque, Jon Arellano, Christopher van Dyck, Randall J. Bateman, Zhongcong Xie, Angus C. Nairn, Amy F. T. Arnsten
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
calcium
CSF
dorsolateral prefrontal cortex
entorhinal cortex
macaque
mGluR3
Online Access:https://doi.org/10.1002/trc2.12431

Internet

https://doi.org/10.1002/trc2.12431

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