Differential requirement of neutralizing antibodies and T cells on protective immunity to SARS-CoV-2 variants of concern

Differential requirement of neutralizing antibodies and T cells on protective immunity to SARS-CoV-2 variants of concern

Abstract The current COVID-19 vaccines protect against severe disease, but are not effective in controlling replication of the Variants of Concern (VOCs). Here, we used the existing pre-clinical models of severe and moderate COVID-19 to evaluate the efficacy of a Spike-based DNA vaccine (pCTV-WS) fo...

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Bibliographic Details
Main Authors: Patrick O. Azevedo, Natália S. Hojo-Souza, Lídia P. Faustino, Marcílio J. Fumagalli, Isabella C. Hirako, Emiliano R. Oliveira, Maria M. Figueiredo, Alex F. Carvalho, Daniel Doro, Luciana Benevides, Edison Durigon, Flávio Fonseca, Alexandre M. Machado, Ana P. Fernandes, Santuza R. Teixeira, João S. Silva, Ricardo T. Gazzinelli
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00616-y

Internet

https://doi.org/10.1038/s41541-023-00616-y

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