The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells

The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells

ABSTRACT Under oxidative stress, viruses prefer glycolysis as an ATP source, and glutamine is required as an anaplerotic substrate to replenish the TCA cycle. Infectious spleen and kidney necrosis virus (ISKNV) induces reductive glutamine metabolism in the host cells. Here we report that ISKNV infec...

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Bibliographic Details
Main Authors: Xiaozhe Fu, Kejin Li, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Lihui Liu, Ningqiu Li
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:Microbiology Spectrum
Subjects:
ISKNV
reductive glutamine metabolism
mTOR
SIRT3
PGC-1α
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02310-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.02310-21

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