Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway

Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway

Airway inflammation and remodeling are critical pathological changes in asthma, and macrophage activation plays a vital role in this process. Sirtuin 1 (SIRT1) reduces airway inflammation by affecting macrophages in asthma. This study aimed to investigate the potential benefit and underlying mechani...

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Bibliographic Details
Main Authors: Dan Huang, Chaoqun Sun, Min Chen, Shuyou Bai, Xuanna Zhao, Weiming Wang, Kang Geng, Wenbo Huang, Tingting Zhao, Bin Wu, Guilin Zhang, Dong Wu, Youhua Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
bergenin
SIRT1
NF-κB
asthma
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.994878/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.994878/full

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