Aβ oligomer induced cognitive impairment and evaluation of ACU193‐MNS‐based MRI in rabbit

Aβ oligomer induced cognitive impairment and evaluation of ACU193‐MNS‐based MRI in rabbit

Abstract Introduction Amyloid‐beta oligomers (AβOs) accumulate in Alzheimer's disease and may instigate neuronal pathology and cognitive impairment. We examined the ability of a new probe for molecular magnetic resonance imaging (MRI) to detect AβOs in vivo, and we tested the behavioral impact...

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Bibliographic Details
Main Authors: Nicholas B. Rozema, Daniele Procissi, Nicola Bertolino, Kirsten L. Viola, Vikas Nandwana, Nafay Abdul, Sophia Pribus, Vinayak Dravid, William L. Klein, John F. Disterhoft, Craig Weiss
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
amyloid‐beta oligomers
biomarkers
dementia
diagnostics
eyeblink conditioning
Online Access:https://doi.org/10.1002/trc2.12087

Internet

https://doi.org/10.1002/trc2.12087

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