Risk of Cardiac Lesion with Chronic and Acute Use of Loperamide—An Integrative Review

Risk of Cardiac Lesion with Chronic and Acute Use of Loperamide—An Integrative Review

Loperamide is a synthetic opioid commonly used as an antidiarrheal due to its activation of u-opioid receptors in the myenteric plexus. In therapeutic doses, it inhibits peristalsis and has anti-secretory and anti-motility effects, until metabolized by intestinal and hepatic CYP3A4 and CYP2C8 into i...

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Bibliographic Details
Main Authors: Bruna Cremonezi Lammoglia, Gabriela Hasselmann, Marcelo Pires-Oliveira, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros, Fernando Sabia Tallo, Murched Omar Taha, Rildo Yamaguti Lima, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
loperamide
opioid-related disorders
cardiotoxicity
long QT syndrome
torsades de pointes
Online Access:https://www.mdpi.com/2308-3425/9/12/431

Internet

https://www.mdpi.com/2308-3425/9/12/431

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