Repurposing CRISPR-Cas13 systems for robust mRNA trans-splicing

Repurposing CRISPR-Cas13 systems for robust mRNA trans-splicing

Abstract Type VI CRISPR enzymes have been developed as programmable RNA-guided Cas proteins for eukaryotic RNA editing. Notably, Cas13 has been utilized for site-targeted single base edits, demethylation, RNA cleavage or knockdown and alternative splicing. However, the ability to edit large stretche...

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Bibliographic Details
Main Authors: David N. Fiflis, Nicolas A. Rey, Harshitha Venugopal-Lavanya, Beatrice Sewell, Aaron Mitchell-Dick, Katie N. Clements, Sydney Milo, Abigail R. Benkert, Alan Rosales, Sophia Fergione, Aravind Asokan
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46172-4

Internet

https://doi.org/10.1038/s41467-024-46172-4

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