In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells

Abstract To enter mitosis, most adherent animal cells reduce adhesion, which is followed by cell rounding. How mitotic cells regulate adhesion to neighboring cells and extracellular matrix (ECM) proteins is poorly understood. Here we report that, similar to interphase, mitotic cells can employ integ...

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Bibliographic Details
Main Authors: Maximilian Huber, Javier Casares-Arias, Reinhard Fässler, Daniel J. Müller, Nico Strohmeyer
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37760-x