ROR2 has a protective role in melanoma by inhibiting Akt activity, cell-cycle progression, and proliferation

ROR2 has a protective role in melanoma by inhibiting Akt activity, cell-cycle progression, and proliferation

Abstract Background Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a Wnt5a receptor aberrantly expressed in cancer that was shown to either suppress or promote carcinogenesis in different tumor types. Our goal was to study the role of ROR2 in melanoma. Methods Gain and loss-of-function st...

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Bibliographic Details
Main Authors: María Victoria Castro, Gastón Alexis Barbero, María Belén Villanueva, Luca Grumolato, Jérémie Nsengimana, Julia Newton-Bishop, Edith Illescas, María Josefina Quezada, Pablo Lopez-Bergami
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Biomedical Science
Subjects:
ROR2
Akt
Melanoma
Wnt5a
Cell-cycle
Proliferation
Online Access:https://doi.org/10.1186/s12929-021-00776-w

Internet

https://doi.org/10.1186/s12929-021-00776-w

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