Synthesis and Characterization of a New Class of Chromene-Azo Sulfonamide Hybrids as Promising Anticancer Candidates with the Exploration of Their EGFR, <i>h</i>CAII, and MMP-2 Inhibitors Based on Molecular Docking Assays

Synthesis and Characterization of a New Class of Chromene-Azo Sulfonamide Hybrids as Promising Anticancer Candidates with the Exploration of Their EGFR, <i>h</i>CAII, and MMP-2 Inhibitors Based on Molecular Docking Assays

In this study, novel selective antitumor compounds were synthesized based on their fundamental pharmacophoric prerequisites associated with EGFR inhibitors. A molecular hybridization approach was employed to design and prepare a range of 4<i>H</i>-chromene-3-carboxylates <b>7a</...

Full description

Bibliographic Details
Main Authors: Fawzia F. Alblewi, Mosa H. Alsehli, Zainab M. Hritani, Areej Eskandrani, Wael H. Alsaedi, Majed O. Alawad, Ahmed A. Elhenawy, Hanaa Y. Ahmed, Mohamed S. A. El-Gaby, Tarek H. Afifi, Rawda M. Okasha
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
4<i>H</i>-chromene
sulfonamide
EGFR
MMP2
molecular docking
Online Access:https://www.mdpi.com/1422-0067/24/23/16716

Internet

https://www.mdpi.com/1422-0067/24/23/16716

Similar Items