The splicing isoform Foxp3Δ2 differentially regulates tTreg and pTreg homeostasis

The splicing isoform Foxp3Δ2 differentially regulates tTreg and pTreg homeostasis

Summary: Foxp3 is the master transcription factor for regulatory T cells (Tregs). Alternative splicing of human Foxp3 results in the expression of two isoforms: the full length and an exon 2-deleted protein. Here, AlphaFold2 predictions and in vitro experiments demonstrate that the N-terminal domain...

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Bibliographic Details
Main Authors: Qianchong Gu, Xiufeng Zhao, Jie Guo, Qiuzhu Jin, Ting Wang, Wei Xu, Liping Li, Jianhua Zhang, Wei Zhang, Sheng Hong, Fuping Zhang, Baidong Hou, Xuyu Zhou
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723008884

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http://www.sciencedirect.com/science/article/pii/S2211124723008884

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