Development and validation of a novel HILIC method for the quantification of low-levels of cuprizone in cuprizone-containing chow

Abstract Cuprizone is an amide compound that has been wildly used in various animal studies, such as in the investigation of remyelination in mouse model. It is important to control the amount of cuprizone dosed in animals to be consistent as different amounts may lead to different clinical observat...

Full description

Bibliographic Details
Main Authors: Fengmei Zheng, Yiqing Lin, Pierre Boulas
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97590-z