Pharmacological Effects of Methotrexate and Infliximab in a Rats Model of Diet-Induced Dyslipidemia and Beta-3 Overexpression on Endothelial Cells

Pharmacological Effects of Methotrexate and Infliximab in a Rats Model of Diet-Induced Dyslipidemia and Beta-3 Overexpression on Endothelial Cells

Background: Hyperlipidemia and inflammation are critical components in the pathophysiology of endothelial disorder, which can lead to vascular complications. Our study aimed to evaluate the effects of immunomodulatory therapy (methotrexate and infliximab) in a diet-induced hyperlipidemia rat model....

Full description

Bibliographic Details
Main Authors: Denisa-Mădălina Zălar, Cristina Pop, Elena Buzdugan, Bela Kiss, Maria-Georgia Ştefan, Steliana Ghibu, Valentin-Adrian Bâlteanu, Doiniţa Crişan, Alexandra Buruiană-Simic, Adriana Grozav, Cristina Ionela Mogoșan
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Journal of Clinical Medicine
Subjects:
high-lipid diet
transgenic rats
beta-3 receptor overexpression
inflammation
oxidative stress
aortic thickening
Online Access:https://www.mdpi.com/2077-0383/10/14/3143

Internet

https://www.mdpi.com/2077-0383/10/14/3143

Similar Items