Vaccine Candidate <named-content content-type="genus-species">Brucella melitensis</named-content> 16M<italic toggle="yes">ΔvjbR</italic> Is Safe in a Pregnant Sheep Model and Confers Protection

Vaccine Candidate <named-content content-type="genus-species">Brucella melitensis</named-content> 16M<italic toggle="yes">ΔvjbR</italic> Is Safe in a Pregnant Sheep Model and Confers Protection

ABSTRACT As a natural host species for Brucella melitensis, pregnant sheep offer an ideal model to evaluate vaccine candidates for safety. B. melitensis strain Rev. 1 has been used almost exclusively to prevent brucellosis in small ruminants, but it causes abortions when given to pregnant animals. T...

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Bibliographic Details
Main Authors: Martha E. Hensel, Daniel G. Garcia-Gonzalez, Sankar P. Chaki, Airn Hartwig, Paul W. Gordy, Richard Bowen, Thomas A. Ficht, Angela M. Arenas-Gamboa
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mSphere
Subjects:
Brucella melitensis
brucellosis
ovine
pregnancy
veterinary vaccine development
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00120-20

Internet

https://journals.asm.org/doi/10.1128/mSphere.00120-20

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