NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer

NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer

Cancer cells, particularly in solid tumors, are surrounded by non-neoplastic elements, including endothelial and stromal cells, as well as cells of immune origin, which can support tumor growth by providing the right conditions. On the other hand, local hypoxia, and lack of nutrients induce tumor ce...

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Bibliographic Details
Main Authors: Valentina Audrito, Antonella Managò, Federica Gaudino, Leonardo Sorci, Vincenzo Gianluca Messana, Nadia Raffaelli, Silvia Deaglio
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
immunometabolism
metabolic reprogramming
immune cell regulation
NAD
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01720/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01720/full

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