Highly Metastatic Subpopulation of TNBC Cells Has Limited Iron Metabolism and Is a Target of Iron Chelators

Highly Metastatic Subpopulation of TNBC Cells Has Limited Iron Metabolism and Is a Target of Iron Chelators

Excess iron is known to be a risk factor of carcinogenesis. Although iron chelators show anti-cancer effects, they have not been used successfully to treat cancer patients. Triple-negative breast cancer (TNBC) is a disease with poor prognosis without effective treatments. Thus, we aimed to evaluate...

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Bibliographic Details
Main Authors: Yuze Wang, Toshiaki Ohara, Yuehua Chen, Yusuke Hamada, Chunning Li, Masayoshi Fujisawa, Teizo Yoshimura, Akihiro Matsukawa
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
triple-negative breast cancer
iron metabolism
iron chelator
phosphoinositide-3-kinase-protein kinase
heterogeneity
metastasis
Online Access:https://www.mdpi.com/2072-6694/15/2/468

Internet

https://www.mdpi.com/2072-6694/15/2/468

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