A novel anti-tumor inhibitor identified by virtual screen with PLK1 structure and zebrafish assay.

A novel anti-tumor inhibitor identified by virtual screen with PLK1 structure and zebrafish assay.

Polo-like kinase 1 (PLK1), one of the key regulators of mitosis, is a target for cancer therapy due to its abnormally high activity in several tumors. Plk1 is highly conserved and shares a nearly identical 3-D structure between zebrafish and humans. The initial 10 mitoses of zebrafish embryonic clea...

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Bibliographic Details
Main Authors: Jing Lu, Shengchang Xin, Huan Meng, Matt Veldman, David Schoenfeld, Chao Che, Ruibin Yan, Hanbing Zhong, Song Li, Shuo Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3637257?pdf=render

Internet

http://europepmc.org/articles/PMC3637257?pdf=render

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