Infant Alveolar Macrophages Are Unable to Effectively Contain Mycobacterium tuberculosis

Infants are more likely to develop lethal disseminated forms of tuberculosis compared with older children and adults. The reasons for this are currently unknown. In this study we test the hypothesis that antimycobacterial function is impaired in infant alveolar macrophages (AMϕs) compared with those...

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Bibliographic Details
Main Authors: Anu Goenka, Ian E. Prise, Emma Connolly, Paulina Fernandez-Soto, David Morgan, Jennifer S. Cavet, John R. Grainger, Jaya Nichani, Peter D. Arkwright, Tracy Hussell
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00486/full