Single-Cell Profiling Shows Murine Forebrain Neural Stem Cells Reacquire a Developmental State when Activated for Adult Neurogenesis

Single-Cell Profiling Shows Murine Forebrain Neural Stem Cells Reacquire a Developmental State when Activated for Adult Neurogenesis

Summary: The transitions from developing to adult quiescent and activated neural stem cells (NSCs) are not well understood. Here, we use single-cell transcriptional profiling and lineage tracing to characterize these transitions in the murine forebrain. We show that the two forebrain NSC parental po...

Full description

Bibliographic Details
Main Authors: Michael J. Borrett, Brendan T. Innes, Danielle Jeong, Nareh Tahmasian, Mekayla A. Storer, Gary D. Bader, David R. Kaplan, Freda D. Miller
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
neural stem cell
single-cell profiling
quiescence
cortex
cortical precursor
ganglionic eminence
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472031007X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472031007X

Similar Items