Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity

Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity

Objective: Obesity is a complex disorder and is linked to chronic diseases such as type 2 diabetes. Major intrinsically disordered NOTCH2-associated receptor2 (MINAR2) is an understudied protein with an unknown role in obesity and metabolism. The purpose of this study was to determine the impact of...

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Bibliographic Details
Main Authors: Saran Lotfollahzadeh, Chaoshuang Xia, Razie Amraei, Ning Hua, Konstantin V. Kandror, Stephen R. Farmer, Wenyi Wei, Catherine E. Costello, Vipul Chitalia, Nader Rahimi
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Molecular Metabolism
Subjects:
Minar2
mTOR
mTORC1
Raptor
Obesity
Diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823000789

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http://www.sciencedirect.com/science/article/pii/S2212877823000789

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