Channelrhodopsin fluorescent tag replacement for clinical translation of optogenetic hearing restoration

Sensory restoration by optogenetic neurostimulation provides a promising future alternative to current electrical stimulation approaches. So far, channelrhodopsins (ChRs) typically contain a C-terminal fluorescent protein (FP) tag for visualization that potentially poses an additional risk for clini...

Full description

Bibliographic Details
Main Authors: Maria Zerche, Christian Wrobel, Kathrin Kusch, Tobias Moser, Thomas Mager
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123000451