Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway

Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway

Summary: Ferroptosis is crucial to the pathology of many neurological diseases. Here, we found pre-treatment with myriocin, an inhibitor of de novo synthesis of sphingolipid, significantly decreased the erastin- or glutamate-induced ferroptosis of HT22 cells without requiring the recovery of intrace...

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Bibliographic Details
Main Authors: Yang Liu, Libo He, Binghua Liu, Yuling Ying, Junling Xu, Meng Yu, Jinye Dang, Ke Liu
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:iScience
Subjects:
Biological sciences
Neuroscience
Cellular neuroscience
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222008045

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http://www.sciencedirect.com/science/article/pii/S2589004222008045

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