Accelerated production of α2,8- and α2,9-linked polysialic acid in recombinant Escherichia coli using high cell density cultivation

Accelerated production of α2,8- and α2,9-linked polysialic acid in recombinant Escherichia coli using high cell density cultivation

Polysialic acid (polySia) are α2,8- and/or α2,9-linked homopolymers with interesting properties for meningococcal vaccine development or the cure of human neurodegenerative disorders.With the goal to avoid large scale production of pathogenic bacteria, we compare in the current study the efficacy of...

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Bibliographic Details
Main Authors: Bastian Bartling, Nora C. Brüchle, Johanna S. Rehfeld, Daniel Boßmann, Timm Fiebig, Christa Litschko, Jörg Fohrer, Rita Gerardy-Schahn, Thomas Scheper, Sascha Beutel
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biotechnology Reports
Subjects:
Escherichia coli
Polysialic acid
High cell density
NMR spectroscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S2215017X2030597X

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http://www.sciencedirect.com/science/article/pii/S2215017X2030597X

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