Regulatory T-cell development in the human thymus

Regulatory T-cell development in the human thymus

The thymus generates a lineage-committed subset of Regulatory T-cells (Tregs), best identified by the expression of the transcription factor FOXP3. The development of thymus-derived Tregs is known to require high avidity interaction with MHC-self peptides leading to the generation of self-reactive T...

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Bibliographic Details
Main Authors: Íris eCaramalho, Helena eNunes-Cabaço, Russell eFoxall, Ana E Sousa
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Immunology
Subjects:
Foxp3
Primary immunodeficiency
regulatory T-cells
Human thymus
Regulatory T-cell Development
Human Thymic Defects
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00395/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00395/full

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